Detectives Mike Lowry (Will Smith) and Marcus Burnett (Martin Lawrence) are partners and friends. To prevent the closure of the Miami Police Department, they have to bring in the drug lord Fouchet (Tchéky Karyo).
But suddenly their jobs and their friendship are on the line when loyal husband Marcus and irresponsible single Mike are forced to impersonate each other.
How far will they go to solve the case?